RELIANT 2 is a pragmatic randomized controlled trial. The goal of this study is to compare the diagnostic yield of robotic assisted bronchoscopy with integrated cone beam computed tomography to that of electromagnetic navigation bronchoscopy with integrated digital tomosynthesis in patients undergoing bronchoscopy to biopsy a pulmonary lesion.

This is a multi-center clinical trial evaluating the effect of transbronchial mediastinal cryobiopsy for its ability to improve the likelihood of obtaining tissue sufficient for molecular analysis.Patients in outpatient clinics or pre-operative holding areas planning to undergo a bronchoscopic biopsy of a suspected malignant lesion (peripheral or mediastinal) for initial diagnosis, staging, or tissue acquisition for molecular analysis will be considered for enrollment and consented.Patients will only be enrolled if intraoperative ROSE suggests malignancy.Patients will be randomized to continue with the operator's initial EBUS-TBNA needle or switch to a cryoprobe to perform a sampling.

This post-market study is a single-arm, prospective, multi-center Registry. It is designed to assess 36-month safety and effectiveness of this FDA approved product in a post-approval setting, and to support the continued assessment of Spiration Valve System therapy for the treatment of severe emphysema in the United States.

Pleural Manometry for the Characterization of Spontaneous and Tension Pneumothorax.

Randomized control trial of forceps versus 1.1mm cryoprobe for transbronchial lung biopsy.

For malignant pleural effusions, randomized clinical trial evaluating bottle suction versus gravity-bag drainage .

Randomized clinical trial assessing use of rapid onsite evaluation, and different methodology for cellblock preparation.

Randomized clinical trial comparing diagnostic yield of robotic-assisted bronchoscopy to electromagnetic navigational bronchoscopy in patients undergoing peripheral pulmonary lesion biopsy.

Randomized control trial assessing peripheral pulmonary nodule biopsy and comparing CT-guided transthoracic biopsy and navigational bronchoscopy.

Randomized clinical trial evaluating adequacy for molecular analysis in EBUS-TBNA specimens versus liquid biopsies.